Evaluation of microbiome-relevant biomarkers and in vitro models for xenobiotic risk assessment
European Food Safety Authority
Prior notice. Estimated value: €300,000.
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Amounts and figures
Description
Addressing a key knowledge gap identified in EFSA's Gut Microbiome Roadmap, the project aims to establish foundational methodological elements for assessing the potential adverse effects of dietary xenobiotics on the gut microbiome and host health through systematic available evidence appraisal and meta-synthesis. In particular, the project will systematically evaluate promising microbiome-relevant biomarkers related to key health endpoints (e.g. intestinal barrier integrity, inflammatory responses, microbiome metabolic capacity, immune system effects, microbiome composition and function) and the suitability of available in vitro models (e.g., SHIME, triple co-culture, MBRA, organoids). It will prioritise optimal biomarker-in vitro model pairings based on regulatory science applicability and feasibility, and identify appropriate analytical methods (including omics-based approaches) for each combination. The outcomes will provide an evidence-based prioritisation framework and feasibility assessment to inform potential follow-up experimental validation of the prioritised biomarker-in vitro model combinations and support the possible integration of microbiome data into risk assessment…
Official publications
| Medium | Reference | Date |
|---|---|---|
| TED | 00054146-2026 | 26 January 2026 |
| OJS | 17/2026 | 26 January 2026 |
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Frequently asked questions
- What is the estimated value of this tender?
- The estimated value published by the buyer is €300,000.
- Who is the buyer of this tender?
- The contracting authority is European Food Safety Authority (European Union).
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