Biological Services- Models Cryopreservation of MHRA Breeding Stock

Amounts and figures

Description

Tenders are invited from establishments who have the capabilities to take on all services related to transgenic colony management. At the MHRA, the Biological Services facility houses two transgenic mouse breeding colonies. These colonies have been specifically bred to support the Poliomyelitis test work implemented by the Science, Research & Innovation Group. In-bred transgenic mice with the Human Polio receptor gene provides a practical alternative to the use of non-human primates. These lines are used to assess the neurovirulence of polioviruses and immunogenicity/ protection of vaccines and hence play a key role in the global polio activities of the Agency. Both colonies require refresh, as genetic drift has been observed due to multiple unexpected phenotypic changes. We are therefore seeking assistance in the maintenance and refresh of colonies, possibly looking to utilise already frozen stocks of embryos/ sperm. Additional information: To express interest and participate in the tender, please register and apply via Atamis e-sourcing portal https://health-family.force.com/s/Welcome. Should Tenderers have any queries, or having problems using the portal, they sh…

Official publications

• Purchase of Serum IgE for replacement WHO standard
  Published: 24 June 2025
• Sterility Testing services
  Published: 13 June 2025
• Biological Services- Models Cryopreservation of MHRA Breeding Stock
  Published: 13 June 2025
• Fermentation Bioreactor
  Published: 4 April 2025
• Purchase of FCS Foetal Calf (Bovine) Serum
  Published: 21 February 2025
• Purchase of Cryogenic Storge Unit Bulk LN2 Storage Tank
  Published: 10 February 2025
• Karyology and Sterility Testing services
  Published: 4 December 2024
• Purchase of Differential Scanning Calorimeter
  Published: 13 December 2023
• Purchase of Liquid handling robot
  Published: 27 November 2023

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Frequently asked questions

What is the deadline to bid for this tender?

The submission deadline is 21 February 2025, 10:00. Check the official source, as dates can be modified.

What is the estimated value of this tender?

The estimated value published by the buyer is £50,000.

Who is the buyer of this tender?

The contracting authority is Medicines and Healthcare Products Regulatory Agency (United Kingdom).

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