timsTOF Pro2 mass spectrometer
Direct award to Bruker Nordic AB.
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Amounts and figures
Description
Karolinska Institute (KI) department Microbiology, Tumor and Cell Biology is focused on high-throughput interaction proteomics using co-fractionation mass spectrometry approaches coupled to short-gradient data-independent acquisition (DIA) for protein-interaction profiling across various biological matrixes including bacteria, phages, viruses, human cells, clinical isolates, and tissue biopsies. The nature of our research requires the ability to perform fast, high-sensitivity LC-MS/MS measurements using gradients shorter than 10 minutes, while maintaining deep proteome coverage, low limits of detection, and sub-one-second cycle times. These analytical requirements are essential to support our ongoing large-scale studies and the rapid processing of complex sample sets. The departments workflow imposes several technical constraints that few instruments can satisfy. We require the ability to perform deep proteome profiling using sub-10-minute gradients while retaining high quantitative accuracy and sensitivity. The mass spectrometer must also support CCS-aware analysis, ensure compatibility with existing and planned nano-LC chromatography systems, and deliver consistent performance a…
Awards
| Lot | Awarded to | Amount | Date |
|---|---|---|---|
| LOT-0000 | Bruker Nordic AB | — | 24 June 2025 |
Official publications
| Medium | Reference | Date |
|---|---|---|
| TED | 00412251-2025 | 26 June 2025 |
| OJS | 120/2025 | 26 June 2025 |
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