Utilising in silico, in vitro and ‘omics New Approach Methodologies (NAMs) for priority-setting and safety assessment of tropane alkaloids (TAs) and other plant toxins as potential food contaminants. A case study for progressing the acceptance of NAMs for
Buyer: Food Standards Agency
- Published
- 27 October 2025
- Estimated value
- £488,376
- Procedure
- Direct award
- Lots
- 1
- Notice number
- 068648-2025
- Reference
- ocds-h6vhtk-0565d3
- Official source
- Official source
CPV codes
- 73110000Research services
- 73200000Research and development consultancy services
Description
Tenders were invited to carry out a range of project delivery options, to deliver against stages 1, 2 and 3 as described below: Stage 1: This case study is to support the UK FSA’s policy need to determine which TAs are the most potent (neuro)toxicants so as to prioritise specific substances and inform decisions on the UK’s monitoring of these alkaloids in foods. An integral part of this aim is to confirm that neurotoxicity is the primary mode of action of these alkaloids. This aim will be achieved using a tiered-testing strategy of in silico, in vitro and ‘omics NAMs. This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 2: To derive a HBGV for human exposure for the top priority, i.e. most potent substance within the class of TAs. This will utilise physiologically-based kinetic (PBK) modelling and quantitative in vitro to in vivo extrapolation (QIVIVE). This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 3: From a methodological perspective, a broader third objective of the case study is to evaluate and attempt to build confidence within the FSA in the application of a serie…
Awards
| Awarded to | Amount | Date |
|---|---|---|
| University of Birmingham | — | — |
Official publications
- FTS · 068648-2025 · 27 October 2025
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