Supply of Endonucleases
Reference ocds-h6vhtk-06ace0 · NHS Blood and Transplant
Prior notice. Estimated value: £87,500.
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Amounts and figures
Description
The Clinical Biotechnology Centre at NHS Blood and Transplant is an MHRA-licensed facility for the manufacture of investigational medicinal products, including advanced therapy medicinal products (ATMPs) and other biotechnology products such as plasmid DNA, viral vectors, and therapeutic proteins. The organisation intends to initiate a procurement process for the supply of advanced, high-performance, and cost-effective endonucleases to support the removal of nucleic acids from ATMPs, particularly gene therapy vectors, including adeno-associated viral (AAV) vectors and lentiviral vectors. The endonuclease must exhibit non-specific nuclease activity against a broad range of nucleic acid substrates, including DNA, RNA, plasmid DNA, synthetically produced DNA, enzymatically produced DNA, and other nucleic acid modalities used in viral vector manufacturing. The enzyme should retain activity under physiological pH and salt conditions, while also maintaining high enzymatic performance across a broad pH and salt concentration range. Demonstrated suitability for use in viral vector manufacturing processes employing HEK293 suspension cells cultured in stirred-tank bioreactors will be conside…
Official publications
| Medium | Reference | Date |
|---|---|---|
| FTS | 052527-2026 | 3 June 2026 |
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Frequently asked questions
- What is the estimated value of this tender?
- The estimated value published by the buyer is £87,500.
- Who is the buyer of this tender?
- The contracting authority is NHS Blood and Transplant (United Kingdom).
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- Bids are submitted through the official public procurement portal in the United Kingdom. El Vínculo helps you find tenders and analyse their documents; submission always happens at the official source.
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