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Prior notice European Union Supplies

Custom-made mRNA (GMP)

Buyer: Radboud Universitair Medisch Centrum/Radboudumc

Published
11 April 2025
Estimated value
€1
Lots
1
Documents
1
Notice number
00236986-2025
Official source
Official source

CPV codes

Description

The Department of Medical BioSciences from Radboudumc has been awarded a KWF grant for the PROTECT-lynch study. The main goal of the PROTECT-lynch study is a new treatment option for LS patients significantly improving the quality of life of LS patients and most likely the prognosis (occurrence of Lynch-related cancer(s). Standard care for healthy LS patients currently consists of undergoing intensive surveillance programs that do not guarantee timely detection of one or more Lynch-related cancers at a treatable stage. The PROTECT-lynch study may change this with its preventive dendritic cell therapy. To prepare the intended dendritic cell (DC) product for the PROTECT-lynch study, mRNA coding for carcino-embryonic antigen (CEA) is required in GMP quality. As the Medical BioSciences department, we have extensive experience in the preparation of DC products in collaboration with the Pharmacy department, in which comparable mRNA was used as raw material for the DC product. The mRNA will form a complex with protamine, which will be added as stimulant to the DC product to fully mature the DCs. For this extensive project the Medical BioSciences department is looking for a reliable suppli…

Official publications

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The estimated value published by the buyer is €1.
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The contracting authority is Radboud Universitair Medisch Centrum/Radboudumc (European Union).
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Data collected from official public procurement sources. Amounts as published by the buyer.